Jun 15, 2011 the labchip gx gxii systems offer researchers an automated alternative by streamlining the multiple, manual steps of slab gel electrophoresis, while also providing the throughput and data quality. Labchip gxii touch protein characterization system perkinelmer. This labchip gx system has been inspected and tested by our technician to ensure. Perkinelmer launches labchip gx touch and gxii touchtm. Aug 01, 2011 vaccine engineering, antibody quality screening, and glycosylation profiling processes can generate large quantities of protein samples that must be analyzed in a timely manner. Product note rapid, costeffective oil condition monitoring spectrum oilexpress system. Under reducing conditions there is a complete shift from the hc to the nghc. Improving the efficiency of metagenomic analysis of stool samples 2018 automated ngs library preparation with covaris focusedultrasonicator workflow solution 2018 labchip gx touch platform applications in epigenetic studies. These features include a shared user account database, access controls, device check, enforced sequencing of run steps, audit trails, record copying, record retention, system documentation, and electronic signature controls. Protein detection and quantification is required for the development of proteinbased therapeutics, as well as research into cell signaling, growth factors, and a variety of disease states. Quick and accurate analysis of rna and dna samples the labchip gx is the most accurate and advanced nucleic acid separations system available. Pe labchip gx touch ht dnarna characterization systemyear 2016.
The proteinexact assay is ideal for use in both upstream and downstream biotherapeutics and gene therapy workflows which require the utmost in precision. Capillary electrophoresis system labchip gxii touch ht. Software determines the relative amounts of glycans present. Labchip instrument diagnostics test chip a false test chip a works in conjunction with test chips c and d to perform a variety of selfdiagnostic tests on the labchip gx and gxii touch instruments.
The labchip gx is the most accurate and advanced nucleic acid separations system available. Dna and rna quantitation and sizing can be done in seconds using automated capillary electrophoresis separation. The software lies within education tools, more precisely science tools. Perkinelmers nexion 2000 is the most versatile icpms on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge. Labchip gxii touch biotherapeutics how a chip works. After connecting a pc and opening the labchip software the status indicator.
The principle of sds pagea full and clear explanation of the technique and how does it work duration. Power requirements 100110230 vac, 5060 hz power consumption 460 va 460 w temperature range. Caliper labchip gx automated electrophoresis rna dna. Part of the labchip training video series if you have any questions after watching this video, please contact technical support.
Our antivirus scan shows that this download is clean. Not recommended or intended for diagnosis of disease in humans or animals. The labchip gx touch and gxii touch benefit customers by reducing handson time and simplifying data. With complete analysis of genomic material in about 30 seconds, the labchip gx touch nucleic acid analyzer eliminates the nucleic acid quantitation workflow bottleneck. Caliper life sciences labchip gx ii automated electrophoresis. The dna high sensitivity assay is for use with labchip gx touch gxii touch instruments. Caliper life sciences introduces labchip gx and gxii. Discover the effortless versatility of an instrument that makes it easy to handle any sample matrix, any interference, and any particle size. Used caliper life sciences labchip gxii 2035202 dna. The labchip platforms key feature is automation of conventional gel electrophoresis, eliminating the need for manual sample preparation. Right click on the link to the file and choose save target as and save the zip file to your desktop. Like its predecessor the labchip90, the gx suite of instruments utilizes perkinelmers innovative microfluidics technology to perform reproducible, highresolution, eletrophoretic separations. This flexible instrument supports multiple assays for.
The labchip gxii platform caliper life sciences is a high throughput ce based analytical technique that can be used to analyze prelabeled mabs directly from whole blood correia ir, unpublished results. Caliper life sciences labchip gxii conquer scientific. The instrument optics detect samples by laserinduced fluorescence. Labchip gxii touch ht protein characterization system perkinelmer. Pe labchip gx touch ht dnarna characterization system. This caliper life sciences labchip gx ii automated electrophoresis system is being sold for parts or repair due to errors encountered during testing. Analysis of each sample is fast, occurring in 40 sec, and the samples are analyzed directly from a 96well plate. The caliper life sciences labchip cxii is a chipbased platform for analyzing dna, rna, protein, and glycan assays. The labchip gx touch software controls the labchip gx touch and labchip gxii touch instruments. Highresolution analysis provides exact sizing and quantitation of dna fragments and smears. When powered on, the chip, eject, and status indicators labchip gxii light up. Labchip instrument diagnostics test chip a test chip a works in conjunction with test chips c and d to perform a variety of selfdiagnostic tests on the labchip gx and gxii touch instruments.
Each individual sample can be analyzed in 41 seconds. The labchip gx represents a system targeted at genomics applications, while the gxii combines both genomics and protein research applications. The labchip gxii is a complete solution for consistent and precise analysis of protein samples, and is an ideal instrument for protein research users. A caliper labchip gxgxii instrument with labchip gxp software is a closed system 21 cfr 11. Labchip gxii touch protein characterization system. Labchip gxii touch software allows users to visualize results via an electropherogram or virtual gel view. High resolution labchip gxii, touch ht perkinelmer.
Jul 16, 2008 the labchip gx represents a system targeted at genomics applications, while the gxii combines both genomics and protein research applications. The labchip gx series of instruments will be marketed by caliper and is designed to provide scientists novel benefits including extended walk away time, higher throughput and plate processing ability. Jul 01, 2012 labchip gxii separation is based on size, with the resolution ranging from 14 to 300 kda. Ht rna pico sensitivity labchip kit labchip gxgxii user guide. Intuitive touch screen interface with comprehensive analysis using labchip gx software enabling true highthroughput analytics. Labchip gxii touch protein characterization system library. Stability of igg isotypes in serum pubmed central pmc. In the field of vaccines and biologics, the labchip gxii has been widely adopted across the discovery and development pipeline by a large number of pharmaceutical and vaccine developers to improve their analytical capabilities for. Labchip gx gxii labchip technology advantages of labchip technology automated sampling from 96 and 384well plates transfer plates from a thermal cycler directly into the labchip gx system, no sample prep or transfer needed. Ce this device complies with all ce rules and requirements. Touch the browse button next to the sample names text box, select the sample names file. Antibody analysis using calipers labchip gxii system abstract current initiatives in process analytical technology pat and quality by design qbd are driving the need to identify and thoroughly understand the relation between critical process parameters cpp and critical quality attributes cqas1.
Ht rna pico sensitivity labchip kit labchip gx gxii user guide caliper life sciences a perkinelmer company page 4 of 22 revised august 2012 68 elm street hopkinton, ma 017481668 1877 labchip 5222447 safety warnings and precautions. The labchip gxii is a complete solution for consistent and precise. Preimplantation genetic testing perkinelmer applied genomics. Less handson time reduces the manual labor associated with gels and frees up valuable resources. Our global laboratories offer one of the worlds most comprehensive genomic screening and testing programs. The actual developer of the free software is perkinelmer inc. The labchip gxii touch system quantifies protein attributes from process development through quality control in biotherapeutics development and manufacturing.
Maurice versus labchip show details in this application note, we compare maurice against perkinelmers labchip gxii touch, a chipbased electrophoretic separation system. Rapid analysis of nglycans on the labchip gxii microchipce. The labchip gx software provides an optical calibration function using test chip c to calculate a correction factor for each individual. The system can be located in a designated laboratory room to limit system access to authorized individuals 21 cfr 11. When using a sample names file to select the wells, only wells with an entry in the sample names file are selected for sampling. The labchip gxgxii electrophoresis systems use a single sipper microfluidic chip to aspirate samples directly from 96 or 384well plates.
The high resolution labchip is designed to be compatible with the glycan screening assay and low molecular weight protein assay on the labchip gxii microfluidic capillary electrophoresis cesds platform. When powered on, the chip, eject, and status indicators labchip gxii light up red. Purchase orders, checks, and wire transfers are preferred. Although still heavily relied upon, sodium dodecyle sulfate polyacrylamide gel electrophoresis sdspage is labor. Leveraging microfluidics technology, the labchip gxii touch 24 eliminates the need to handle time consuming sds page gels. The labchip gx touch nucleic acid analyzers microfluidic technology generates reproducible, highresolution data and is optimal for. A high throughput microchipce method on the labchip gxii has been developed for profiling nglycans from. Labchip gxii touch ht protein characterization system. The labchip gxii is a complete solution for consistent and precise analysis of protein samples and is an ideal instrument for protein research users. A high throughput capillary electrophoresis method to obtain.
Leveraging microfluidics technology, the labchip gxii touch ht eliminates the need to handle time consuming sds page gels, and provides superior results for less time and money. Calipers labchip gx instruments address needs of proteomic. Quantitation given by the labchip gx software should be mul tiplied by the dilution factor i. Labchip gx touch nucleic acid analyzer perkinelmer applied. The dna 12k labchip kit for use on the labchip gx and labchip gx touch systems provides a fast and easy way to analyze a dna samples ranging from 100 to 12,000 base pairs, which is an extended size range relative to the companion assays in the perkinelmer portfolio. Software iq report if selected, the results of software iq tests are printed. The software contains an application security module for user account management and for access of controls to. Used perkin elmer labchip gx touch 24 microfluidic. Labchip gx ii electrophoresis system w software this caliper life sciences labchip gx ii automated electrophoresis system is being sold for parts or repair due to errors encountered during testing. Labchip gx touch nucleic acid analyzer perkinelmer. Read perkinelmers applied genomics blog to learn how to improve the efficiency of your work in the applied genomics field. There was a 4 log linear range of detection lower limit of detection was about 10 pg. Labchip proteinexact assay perkinelmer applied genomics. Used labchip software to connect pc to labchip gx system.
Both systems combine calipers highly reproducible assay technology with advanced data analysis and visualization software. The ht protein express 200 assay was run on the labchip gxii as a control to test for the level of deglycosylation. Labchip instrument diagnostics test chip a perkinelmer. Caliper labchip the labchip gxii is a complete solution for consistent and precise analysis of protein samples, and is an ideal instrument for protein research users. The technology automatically stains distains, electrophoretically separates and analyzes the protein samples. Jul 27, 2010 labchip gxii technology for vaccines and biologics 10x increase in yield possible due to high throughput expression monitoring. Labchip gxii touch microfluidics capillary electrophoresis. The software then shows an alert warning barcode reader disconnected and no chip. Electropherogram showing complete digestion by pngasef after 1h labeling of standards. Perkinelmer labchip gxii touch ht capillary electrophoresis.
The labchip gxii touch system is a complete solution for consistent and precise analysis of protein samples. This chip works with the following reagent kits sold separately. Read our library of application notes and flyers to learn more about the labchip gxii touch protein characterization system. Labchip gx touch microfluidics for dnarna analysis youtube. Whether it is quantitating monoclonal antibody titers, optimizing protein expression conditions, or rapidly screening igg nglycan profiles, the labchip gxii is the perfect benchtop tool to. The labchip gxii touch protein characterization system provides the complete solution for reproducible quantitation, molecular weight sizing and percent purity analysis of protein samples. Leveraging microfluidic electrophoretic separation technology, the labchip gxii touch system enables rapid characterization with minimal sample.
Perkinelmer has led the way for over 25 years with powerful software and informatics solutions. The foundationfocus cdx brca assay is intended to be performed with serial numbercontrolled instruments as indicated in table 3 below. New features the following new assays are added and supported in labchip gx gxii touch 1. The information in this section is from caliper labchip gxgx ii user manual how the caliper software analyzes rna data. It operates via standard gel electrophoresis principles with microvolumes for sample acquisition times as low as 40 seconds. The labchip gx is designed for both rna and dna analysis, while the labchip gxii runs rna, dna, and also protein assays. Perkinelmer labchip gx touch user manual pdf download. Sampling directly from a 96 or 384well plate, the lcgxii offers ease of use and walk away time. After connecting a pc and opening the labchip software the status indicator turns green. The labchip gx touch system provides rapid, quantifiable data for pre and postpcr sample analysis, which is critical for nextgeneration sequencing and genomics workflows. With 96well and 384well plate compatibility and the ability to select single wells at any location in a plate, the labchip gx and gxii systems provide researchers with unmatched throughput, flexibility, and performance. Caliper labchip gx automated electrophoresis rna dna analysis. Leveraging microfluidics technology, the labchip gxii touch ht eliminates, the need to handle timeconsuming sds page gels, and provides superior results for less time and money. Increase efficiency and accelerate protein workflows with the.
Additionally it provides data in tabular form, which can then be analyzed or easily exported into a spreadsheet format. Rapid analysis of nglycans on the labchip gxii microchip. The labchip gxii lcgxii platform shown in figure 1 provides an automated platform for rapid analysis of proteins and nucleic acids. Whether it is quantitating monoclonal antibody titers, optimizing protein expression conditions, or rapidly screening igg nglycan profiles, the labchip gxii is the perfect benchtop tool to accelerate your research and meet your goals. The labchip gx rna assay analysis determines the quality of the rna sample by measuring the relative amounts of know rna fragments relative to the total rna present in the sample. Credit card and paypal payments are accepted, but may be subject to. Use the links below to quickly find your software solution download. Note changes or modifications to this equipment not expressly approved by the party. The perkin elmer labchip gxii system provides throughput and data quality for life science laboratories. Fda summary of safety and effectiveness data page 4 shipping instructions return shipping label technical information summary. Labchip gxii touch biotherapeutics how a chip works youtube.
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